Circulating tumor cells in prostate cancer: Does (nuclear) size matter?
نویسندگان
چکیده
منابع مشابه
Circulating Tumor Cells in Prostate Cancer
Circulating tumor cells (CTCs) can provide a non-invasive, repeatable snapshot of an individual patient's tumor. In prostate cancer, CTC enumeration has been extensively studied and validated as a prognostic tool and has received FDA clearance for use in monitoring advanced disease. More recently, CTC analysis has been shifting from enumeration to more sophisticated molecular characterization o...
متن کاملPrevalence of circulating tumor cells in localized prostate cancer.
BACKGROUND Circulating tumor cells (CTC) predict overall survival in patients with metastatic prostate cancer. The objective of this study is to measure CTC before radical prostatectomy in intermediate- and high-risk prostate cancer patients. MATERIALS AND METHODS The study accrued 12 patients and 10 provided adequate peripheral blood sample. Blood was drawn preoperatively and assayed for CTC...
متن کاملCirculating tumor cells in prostate cancer: beyond enumeration.
Circulating tumor cells (CTCs) are a population of rare cancer cells that have detached from the primary tumor and/or metastatic lesions and entered the peripheral circulation. Enumeration of CTCs has demonstrated value as a prognostic biomarker, and newer studies have pointed to information beyond enumeration that is of critical importance in prostate cancer. Technologic advances that permit e...
متن کاملCCR 20th Anniversary Commentary: Circulating Tumor Cells in Prostate Cancer.
Circulating tumor cells (CTC) have substantial promise for multipurpose biomarker studies in prostate cancer. The IMMC-38 trial conducted by de Bono and colleagues, which was published in the October 1, 2008, issue of Clinical Cancer Research, demonstrated for the first time that CTCs are the most accurate and independent predictor of overall survival in metastatic prostate cancer. Since the pu...
متن کاملCirculating Tumor Cells in Biochemical Recurrence of Prostate Cancer.
OBJECTIVE Circulating tumor cells (CTCs) have known prognostic implications in metastatic castration-resistant prostate cancer, but little is known regarding its utility in biochemical recurrence (BR) of prostate cancer. The primary objectives were to determine whether CTCs are measurable in patients with BR and whether it can reliably predict prostate-specific antigen (PSA) increase and PSA do...
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ژورنال
عنوان ژورنال: Cancer
سال: 2015
ISSN: 0008-543X
DOI: 10.1002/cncr.29454